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The antidepressant-like effects of aloysia polystachya (Griseb.) moldenke (Verbenaceae) in mice.

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dc.contributor.author Hellión-Ibarrola, María del Carmen
dc.contributor.author Ibarrola, Derlis A.
dc.contributor.author Montalbetti, Yenny
dc.contributor.author Kennedy, María Luisa
dc.contributor.author Heinichen, Olga Y.
dc.contributor.author Campuzano, M. A.
dc.contributor.author Ferro, Esteban A.
dc.contributor.author Alvarenga, Nelson L.
dc.contributor.author Tortoriello, J.
dc.contributor.author De Lima, Thereza C. M.
dc.contributor.author Mora, Sergio
dc.date.accessioned 2019-12-21T19:58:14Z
dc.date.available 2019-12-21T19:58:14Z
dc.date.issued 2008
dc.identifier.issn 0944-7113
dc.identifier.uri http://dspace.conacyt.gov.py/xmlui/handle/123456789/42463
dc.description.abstract The aim of the present work is to evaluate the putative antidepressant-like effects of a hydro-ethanolic extract (CEAp) and their fractions from the aerial parts of Aloysia polystachya (Griseb.) Moldenke (Verbenaceac) on the performance of male mice in the forced swimming test (FST). A single dose (100.0 mg/kg p.o.) of CEAp, in male mice provoked a significant reduction of the immobility time (p < 0.01). Such effect was also observed with short-term treatment (7 days) with single doses of 1.0 (p < 0.01), 10.0 (p < 0.05) and 100.0 (p<0.05)mg/kg/day of CEAp. Additionally, in a different set of experiments, repeated administration in a 24-h period (24, 18 and I h before swimming test) with doses of 1.0 (p < 0.05) and 10.0 (p < 0.05) mg/kg p.o., of CEAp and 10.0 mg/kg p.o., (p < 0.05) of ethyl acetate fraction, provoked significant reduction of the immobility time of male mice in the FST. Moreover, it was noted important differences in the onset of the antidepressant-like effect in the FST, depending on the modality of treatment with CEAp (acute, short-term or repeated). Both, efficacy and potency were higher when repeated administration of CEAp was used, and surprisingly the dose of 10 mg/kg (24, 18 and I h before swimming test) was more effective than imipramine. In the same way, the short term administration (7 days) improved significantly efficacy and potency of the CEAp in comparison to a single dose treatment. The ethyl acetate fraction submitted to TLC demonstrated that main and minor components are phenolics and terpenes, respectively. In addition, this fraction gives a negative Shinoda's test for flavonoids. These results indicate an antidepressant-like profile of action for the hydro-ethanolic extract and the component(s) of the ethyl acetate fraction obtained from A. polystachya, which deserve further investigation. CYTED Program (Iberoamerican Program of Science and Technology for Development) Subprogram X-Pharmaceutical Fine Chemistry Project X.8 "Obtencion de medicamentos innovadores con actividad ansiolitica/antidepresiva a partir de plantas medicinales Iberoamericanas validadas
dc.format application/pdf
dc.language Inglés
dc.relation.uri http://dspace.conacyt.gov.py/jspui/bitstream/123456789/42463/1/2008 the antidepressant-like effects of aloysia polystachya (griseb.) moldenke (verbenaceae) in mice.pdf
dc.source Phytomedicine
dc.subject Aloysia polystachya
dc.subject Verbenaceae
dc.subject Antidepressant effect
dc.subject Forced swimming test
dc.subject Immobility
dc.title The antidepressant-like effects of aloysia polystachya (Griseb.) moldenke (Verbenaceae) in mice.
dc.type Artículo
dcterms.bibliographicCitation Phytomedicine 15(2008), 478 -483. 2008
dc.contributor.identifier 522337
dc.contributor.identifier 494413
dc.contributor.identifier 978233
dc.contributor.identifier 1288981
dc.contributor.identifier 444503
dc.contributor.identifier 1026426
dc.contributor.identifier 853145
dc.contributor.identifier 1143258
dc.directorio.catalogador mgt
dc.directorio.index [Indexed for MEDLINE]
dc.identifier.doi 10.1016/j.phymed.2007.11.018
dc.source.pages 478 -483
dc.source.volume 15
dc.source.volume 2008


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