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Evaluation of anti-aggressive activity of kyllinga brevifolia in rodent model of aggression.

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dc.contributor.author Hellion-Ibarrola, M.
dc.contributor.author Kennedy, Miguel A.
dc.contributor.author Campuzano Bublitz's, Miguel
dc.contributor.author Montalbetti, Yenny
dc.contributor.author Heinichen, Olga Y.
dc.contributor.author Ibarrola, Derlis A.
dc.date.accessioned 2019-12-21T19:58:03Z
dc.date.available 2019-12-21T19:58:03Z
dc.date.issued 2014
dc.identifier.issn 2312-3710
dc.identifier.uri http://dspace.conacyt.gov.py/xmlui/handle/123456789/42455
dc.description.abstract Kyllinga brevifolia Rottb, Cyperaceae, rhizomes are used in the Paraguayan folk medicine as sedative and tonic for nervous system. The aim of this study was to determine the anti-aggressive activity of hydro-ethanolic (rhizomes) extract (CEKb), hexane (KbF-hex), chloroform (KbF-chlo), ethyl acetate (KbF-ethyl-ac) and aqueous (KbF-aq) fractions of K. brevifolia on the aggressive behavior assessed in the isolation-induced aggression model in male mice. The effect on aggressive behavior was observed during a ten minute resident-intruder confrontation. Oral doses of CEKb (10 and 100 mg/kg; p< 0.05), KbF-hex (0.1, p<0.01; 1, p<0.001 and 10 mg/kg, p< 0.01)) and KbF-ethyl-ac (0.1, p<0.01; 1, p< 0.05 and 10 mg/kg, p< 0.05) from K. brevifolia reduced fighting time of isolation-induced aggressive behavior, respectively, in male mice. In conclusion, our results make evident that CEKb, Hex Kb and KbF-ethyl-ac obtained from K. brevifolia possesses anti aggressive-like property in mice. These finding give further support to the traditional use of Kyllinga brevifolia as sedative and tonic in Paraguayan folk medicine. Taken together, these findings suggest that Kyllinga brevifolia exhibits a general anti-offensive aggressive activity and may be relevant in the treatment of reactive aggression in humans.
dc.format application/pdf
dc.language Inglés
dc.relation.uri http://dspace.conacyt.gov.py/jspui/bitstream/123456789/42455/1/2014 evaluation of anti-aggressive activity of kyllinga brevifolia in rodent model of aggression.pdf
dc.source Journal of Advanced Clinical Pharmacology
dc.subject Kyllinga brevifolia
dc.subject Anti-aggressive
dc.subject Fighting time
dc.subject Isolation-induced
dc.subject Aggressive behavior
dc.title Evaluation of anti-aggressive activity of kyllinga brevifolia in rodent model of aggression.
dc.type Artículo
dcterms.bibliographicCitation Journal of Advanced Clinical Pharmacology 1(1), 3 - 7. 2014
dc.contributor.identifier 522337
dc.contributor.identifier 1288981
dc.contributor.identifier 1143258
dc.contributor.identifier 978233
dc.contributor.identifier 1026426
dc.contributor.identifier 494413
dc.directorio.catalogador mgt
dc.identifier.doi 10.14205/2312-3710.2014.01.01.1
dc.source.pages 3 - 7
dc.source.volume 1
dc.source.volume 1


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