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Anxiolytic-like and sedative effects of kyllinga brevifolia in mice

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dc.contributor.author Hellión-Ibarrola, María del Carmen
dc.contributor.author Montalbetti, Yenny
dc.contributor.author Heinichen, Olga Y.
dc.contributor.author Kennedy, Miguel A.
dc.contributor.author Campuzano Bublitz's, Miguel
dc.contributor.author Ibarrola, Derlis A.
dc.date.accessioned 2019-12-21T19:57:34Z
dc.date.available 2019-12-21T19:57:34Z
dc.date.issued 2012
dc.identifier.issn 0102-695X
dc.identifier.uri http://dspace.conacyt.gov.py/xmlui/handle/123456789/42431
dc.description.abstract Kyllinga brevifolia Rottb., Cyperaceae, rhizomes have been widely used in the Paraguayan folk medicine as digestive, diuretic, sedative, tonic, antispasmodic and sudorific. The purpose of this study is to characterize the putative sedative, anxiolytic effects of the crude hydro-ethanolic extract (CEKb) and fractions of the rhizome of K. brevifolia, in male mice. The behaviour of mice was assessed in the open field, hole board, rota-rod and elevated plus-maze (EPM) test. Oral treatment with single doses of 10, 100 and 1000 mg/kg of CEKb and 10 mg/kg of ethyl acetate fraction (KbF-ethyl-ac) increased the duration of the sleeping time induced by pentobarbital. Oral administration of 1, 10 and 100 mg/kg of CEKb and 0.1, 1 and 10 mg/kg of KbF-ethyl-ac also significantly increased the time-spent and arm entries into open arms of the elevated plus maze (EPM) versus control group. These findings indicate that K. brevifolia exerts a weak sedative and an interesting anxiolytic-like effect in mice and suggest its potential usefulness for the treatment of anxiety in humans.
dc.format application/pdf
dc.language Inglés
dc.relation.uri http://dspace.conacyt.gov.py/jspui/bitstream/123456789/42431/1/2012 anxiolytic-like and sedative effects of kyllinga brevifolia in mice.pdf
dc.source Revista brasileira de farmacognosia
dc.subject Anxiolytic
dc.subject Elevated plus-maze
dc.subject Hole board
dc.subject Kyllinga brevifolia
dc.subject Open field
dc.subject Pharmacy and materia medica
dc.subject Rs1-441
dc.subject Medicine
dc.subject Farmacia
dc.title Anxiolytic-like and sedative effects of kyllinga brevifolia in mice
dc.type Artículo
dcterms.bibliographicCitation Revista brasileira de farmacognosia 22(6), 1323 - 1329. 2012
dc.contributor.identifier 522337
dc.contributor.identifier 978233
dc.contributor.identifier 1026426
dc.contributor.identifier 1288981
dc.contributor.identifier 1143258
dc.contributor.identifier 494413
dc.directorio.catalogador mgt
dc.identifier.doi 10.1590/S0102-695X2012005000112
dc.source.number 6
dc.source.pages 1323 - 1329
dc.source.volume 22


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