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The anxiolytic-like effects of aloysia polystachya (Griseb.) Moldenke (Verbenaceae) in mice.

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dc.contributor.author Ibarrola, Derlis. A.
dc.contributor.author Hellión-Ibarriola, María del Carmen
dc.contributor.author Montalbetti, Yenny
dc.contributor.author Heinichen, Olga Y.
dc.contributor.author Campuzano Bublitz's, Miguel
dc.contributor.author Kennedy, María Luisa
dc.contributor.author Tortoriello, J.
dc.contributor.author De Lima, Thereza C.M.
dc.contributor.author Mora, Sergio
dc.contributor.author Wasowsky, C.
dc.date.accessioned 2019-12-21T19:57:28Z
dc.date.available 2019-12-21T19:57:28Z
dc.date.issued 2006
dc.identifier.issn 0378-8741
dc.identifier.uri http://dspace.conacyt.gov.py/xmlui/handle/123456789/42425
dc.description.abstract The aim of the present work is to demonstrate the putative sedative and anxiolytic-like effects of a hydro-ethanolic extract obtained from the aerial parts of Aloysia polystachya (Verbenaceae) in male mice using several behavioural assays. Groups of male mice orally treated with doses of 1.0, 10.0 and 100.0 mg/kg of the extract did not show any significant alteration of their locomotor activity, body temperature or motor coordination. The same treatment increased the duration of the sleeping time induced by 30.0 mg/kg i.p. of sodium pentobarbital. However, the sleeping time induced by ethyl ether was not modified by the oral administration of the extract, not confirming the putative sedative effect of the plant. The ethanolic extract also significantly increased the percentage of both entries (1.0 and 100.0 mg/kg) and the time spent (10.0 and 100.0 mg/kg) into the open arms of the elevated plus maze (EPM). Nevertheless, the binding of 3H-flunitrazepam (3H-FNZ) to the benzodiazepine binding site (BDZ-bs), in washed crude synaptosomal membranes from rat cerebral cortex, was not affected by the semi-purified components from Aloysia polystachya. These results indicate an anxiolytic-like profile of action for the extract of Aloysia polystachya without sedative side effect, being this activity probably mediated by other mechanism than BDZ-bs modulation at the GABAA receptors.
dc.format application/pdf
dc.relation.uri http://dspace.conacyt.gov.py/jspui/bitstream/123456789/42425/1/2006 the anxiolytic-like effects of aloysia polystachya (griseb.) moldenke (verbenaceae) in mice.pdf
dc.source Journal of Ethnopharmacology
dc.subject Aloysia polystachya
dc.subject Verbenaceae
dc.subject Anxiolytic
dc.subject Elevated plus maze
dc.subject Hole-board
dc.subject Open-field
dc.subject Benzodiazepine binding assay
dc.title The anxiolytic-like effects of aloysia polystachya (Griseb.) Moldenke (Verbenaceae) in mice.
dc.type Artículo
dcterms.bibliographicCitation Journal of Ethnopharmacology 105(3), 400 - 408. 2006
dc.contributor.identifier 494413
dc.contributor.identifier 522337
dc.contributor.identifier 978233
dc.contributor.identifier 1288981
dc.contributor.identifier 1026426
dc.contributor.identifier 1143258
dc.identifier.doi https://doi.org/10.1016/j.jep.2005.11.013
dc.source.number 3
dc.source.pages 400 - 408
dc.source.volume 105


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