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Isolation of hypotensive compounds from Solanum sisymbriifolium Lam.

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dc.contributor.author Ibarrola, Derlis A.
dc.contributor.author Hellión Ibarrola, María C.
dc.contributor.author Montalbetti, Yenny
dc.contributor.author Heinichen, Olga Y.
dc.contributor.author Alvarenga, Nelson
dc.contributor.author Figueredo, Antonio
dc.contributor.author Ferro, Esteban A.
dc.date.accessioned 2019-12-21T19:57:26Z
dc.date.available 2019-12-21T19:57:26Z
dc.date.issued 2000
dc.identifier.issn 0378-8741
dc.identifier.uri http://dspace.conacyt.gov.py/xmlui/handle/123456789/42424
dc.description.abstract The crude hydroalcoholic root extract (CRE) of Solanum sisymbriifolium Lam. has formerly been shown to have hypotensive activity both in normo-and hypertensive rats. Hypotensive activity-guided fractionation of the CRE was performed in anaesthetized normotensive rats, which led to the isolation of the active principles. The intravenous (i.v.) and intraperitoneal (i.p.) values of the CRE in mice were found to be, respectively, 343 and 451 mg/kg, and no lethal effect was caused by doses up to 5.0 g/kg when administered by oral route. Depression of locomotion, increase of breathing rate and piloerection was observed in a general behavior test with doses up to 200 mg/kg i.p., and 1000 mg/kg p.o., respectively. Increase in the gastrointestinal transit was found using 0.1 g/kg, whereas at doses of 0.5 and 1 g/kg, no significant activity was observed in comparison with the control mice. Hexanic and butanolic fractions induced a remarkable hypotension in anaesthetized normotensive rats in doses of 1, 5, 7.5 and 10 mg/kg i.v. Two compounds isolated from the butanolic fraction induced a significant decrease of the blood pressure, HR, amplitude of the ECG and breathing rate when injected in a dose of 1 mg/kg i.v; and both systofic and diastolic, blood pressures were affected in a proportional mode. The hypotensive effect of the two compounds were not influenced by pretreatment with atropine and propranolol; and the pressor response to noradrenaline was not affected by any of them which suggests that neither a direct muscarinic activity, β-adrenoceptor activation nor decrease of sympathetic vascular tone (sympatholitic activity) are probably involved in the mechanism of hypotension. The present study shows that the CRE of S. sisymbriifolium contains at least two hypotensive compounds whose characterization is under way.
dc.format application/pdf
dc.language Inglés
dc.relation.uri http://dspace.conacyt.gov.py/jspui/bitstream/123456789/42424/1/2000 isolation of hypotensive compounds from solanum sisymbriifolium lam.pdf
dc.source Journal of Ethnopharmacology
dc.subject Solanum sisymbriifolium
dc.subject Acute toxicity
dc.subject Gastrointestinal transit
dc.subject General behavior
dc.subject Hypotensive activity
dc.subject Isolation
dc.title Isolation of hypotensive compounds from Solanum sisymbriifolium Lam.
dc.type Artículo
dcterms.bibliographicCitation Journal of Ethnopharmacology 70(2000), 301 - 307. 2000
dc.contributor.identifier 494413
dc.contributor.identifier 522337
dc.contributor.identifier 978233
dc.contributor.identifier 1026426
dc.contributor.identifier 853145
dc.contributor.identifier 444503
dc.directorio.catalogador mgt
dc.directorio.index [Indexed for MEDLINE]
dc.identifier.doi 10.1016/S0378-8741(00)00191-4
dc.source.pages 301 - 307
dc.source.volume 70
dc.source.volume 2000


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