Studies on quinones . part 36.' synthesis and trypanocidal activity of 2 alkoxycarbonylbenzo[6]thiophene-4,7-quinones.

Rojas de Arias, Gladys Antonieta; Pessoa-Mahana, Carlos D.; Valderrama, Jaime A.; Olmos, María G.; Espinoza, Omar A.; Pessoa-Mahana, Hernán; Nakayama, Héctor; Torres, Susana; Miret, Jorge

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Studies on quinones . part 36.' synthesis and trypanocidal activity of 2 alkoxycarbonylbenzo[6]thiophene-4,7-quinones.

Rojas de Arias, Gladys Antonieta; Pessoa-Mahana, Carlos D.; Valderrama, Jaime A.; Olmos, María G.; Espinoza, Omar A.; Pessoa-Mahana, Hernán; Nakayama, Héctor; Torres, Susana; Miret, Jorge

URI: http://dspace.conacyt.gov.py/xmlui/handle/123456789/42365

Date: 2002

Abstract:

A series of 2-alkoxycarbonylbenzo[b]thiophene-4,7-quinones (11-15), prepared from the corresponding acid 5, were tested in vitro against trypomastigote form of Trypanosome cruzi. The influence of the lypophilia and oxidant capacity upon the trypanocidal activity of these members is discussed.

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