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Leishmanicidal activity of two canthin-6-one alkaloids, two major constituents of Zanthoxylum chiloperone var. Angustifolium.

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dc.contributor.author Rojas de Arias, Gladys Antonieta
dc.contributor.author Ferreira, María Elena
dc.contributor.author Torres, Susana
dc.contributor.author Inchausti, Alba
dc.contributor.author Nakayama, Héctor
dc.contributor.author Thouvenel, C.
dc.contributor.author Hocquemiller, R.
dc.contributor.author Fournet, Alain
dc.date.accessioned 2019-12-21T19:56:05Z
dc.date.available 2019-12-21T19:56:05Z
dc.date.issued 2002
dc.identifier.issn 0378-8741
dc.identifier.uri http://dspace.conacyt.gov.py/xmlui/handle/123456789/42317
dc.description.abstract The crude alkaloidal extract of Zanthoxylum chiloperone stem bark exhibited in vitro activity against various strains of Leishmania ssp. at 100 μg/ml. Two active major constituents were isolated and identified as canthin-6-one and 5-methoxycanthin-6-one. The effect of these compounds was also tested in an in vivo assay using BALB/c mice infected with Leishmania amazonensis. The mice were treated for 5 weeks postinfection with these alkaloids by oral (14 days) or intralesional route (4 days) at 10 mg/kg daily. The reference drug, N-methylglucamine antimonate was administered by subcutaneous injections at 100 mg/kg for 10 days. Intralesional administration of canthin-6-one reduced the parasite burden but not significantly when it was compared with the untreated group, while the reference drug reduced by 91% the parasite loads in the lesion.
dc.format application/pdf
dc.relation.uri http://dspace.conacyt.gov.py/jspui/bitstream/123456789/42317/1/2002 leishmanicidal activity of two canthin-6-one alkaloids, two major constituents of zanthoxylum chiloperone var. angustifolium.pdf
dc.source Journal of Ethnopharmacology
dc.subject Zanthoxylum chiloperone
dc.subject Rutaceae
dc.subject Canthin-6-one
dc.subject 5-Methoxycanthin-6-one
dc.subject BALB/c mice
dc.subject Leishmania amazonensis
dc.title Leishmanicidal activity of two canthin-6-one alkaloids, two major constituents of Zanthoxylum chiloperone var. Angustifolium.
dc.type Artículo
dcterms.bibliographicCitation Journal of Ethnopharmacology 80(2-3), 199 - 202. 2002
dc.contributor.identifier 1261551
dc.contributor.identifier 517692
dc.contributor.identifier 669107
dc.contributor.identifier 1201818
dc.identifier.doi https://doi.org/10.1016/S0378-8741(02)00025-9
dc.source.number 2-3
dc.source.pages 199 - 202
dc.source.volume 80


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