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The effect of bisbenzylisoquinoline alkaloids on Trypanosoma cruzi infections in mice.

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dc.contributor.author Rojas de Arias, Gladys Antonieta
dc.contributor.author Ferreira, María-Elena
dc.contributor.author Fournet, Alain
dc.contributor.author Schinini, Alicia
dc.contributor.author Nakayama, Héctor
dc.contributor.author Torres, Susana
dc.contributor.author Sanabria, Ramonita
dc.contributor.author Guinaudeau, Helène
dc.contributor.author Bruneton, Jean
dc.date.accessioned 2019-12-21T19:55:52Z
dc.date.available 2019-12-21T19:55:52Z
dc.date.issued 1997
dc.identifier.issn 0924-8579
dc.identifier.uri http://dspace.conacyt.gov.py/xmlui/handle/123456789/42286
dc.description.abstract Five bisbenzylisoquinoline (BBI) alkaloids, curine, cycleanine, isotet:andrine, limacine and pheanthine were tested for trypanocidal activity in C 3H He mice infected with Y or CL strain of Trypanosoma cruzi. The activity was compared with the baseline drug, benznidazole. Oral treatment was more effective with curine at 10 mg/kg or with cycleanine at 2 mg/kg daily for 10 days in mice infected with Y or CL strain. In these groups, the parasitemias were negative after 5-7 weeks after inoculation and mortality time 50 (MT(50)) was significantly higher than untreated mice. Benznidazole was effective in mice infected with CL strain but not in mice infected with Y strain. The other BBI showed a relative efficacy against both strains. The effect of BBI alkaloids could be due to a blocking of the Ca2+ channel for the regulation of T. cruzi infectivity to invade host cells or their selective immunosuppressive properties.
dc.format application/pdf
dc.relation.uri http://dspace.conacyt.gov.py/jspui/bitstream/123456789/42286/1/1997 the effect of bisbenzylisoquinoline alkaloids on trypanosoma cruzi infections in mice.pdf
dc.source International Journal of Antimicrobial Agents
dc.subject Chagas' disease
dc.subject Trypanosoma cruzi
dc.subject Trypomastigotes
dc.subject Bisbenzylisoquinoline
dc.subject C,H/He mice
dc.subject Benznidazole
dc.subject Curine
dc.subject Cycleanine
dc.subject Isotetrandrine
dc.subject Limacine
dc.subject Pheanthine
dc.title The effect of bisbenzylisoquinoline alkaloids on Trypanosoma cruzi infections in mice.
dc.type Artículo
dcterms.bibliographicCitation International Journal of Antimicrobial Agents 8([S.N]), 163 - 170. 1997
dc.contributor.identifier 1261551
dc.contributor.identifier 517692
dc.contributor.identifier 294795
dc.contributor.identifier 1201818
dc.contributor.identifier 669107
dc.identifier.doi 10.1016/S0924-8579(97)00373-7
dc.source.number 3
dc.source.pages 163 - 170
dc.source.volume 8


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